TEAMFIGHT COMBOS
In teamfights, use Irithel's Ultimate at the start to enhance her Basic Attacks, then use her 1st Skill to reduce the enemies' Defense and use her Basic Attacks to hit multiple enemies. Use her 2nd Skill to slow enemies and prevent them from getting close.
LANING COMBOS
In the laning phase, Irithel should maintain distance from the enemy and use her 1st Skill to reduce their Defense. Kite the enemy with Basic Attacks to chip away their HP. If the enemy tries to close in, use her 2nd Skill to maintain distance and continue firing Basic Attacks. When the time is right, use her Ultimate to enhance her Basic Attacks and finish off the enemy.